Losartan and Apixaban Interaction: Safety, Risks, and Monitoring
Can you take losartan with apixaban? What is established about the interaction, what is only plausible, and what monitoring a clinician or pharmacist should verify.
Losartan: Drug Interactions
23 source-based articles maintained by the HealthRX.com Editorial Team.
23articles
3topic areas covered
May 27, 2026latest review
Losartan: Drug Interactions library
Showing 23 of 23 clinical reviews.
Losartan and Benzodiazepines Interaction: Risks, Monitoring, and Clinical Guidance
Can you take losartan with benzodiazepines? A clinician-grade review of the pharmacokinetic and pharmacodynamic interaction, severity ratings, dose adjustments, and patient counseling.
Losartan and Bupropion Interaction: What You Need to Know
A clinical guide to the losartan and bupropion drug interaction, covering CYP2D6 inhibition, blood pressure effects, monitoring protocols, and dose-adjustment strategies.
Losartan and Clopidogrel Interaction: CYP2C9 Overlap, Clinical Risk, and Monitoring
Losartan and clopidogrel share CYP2C9 metabolism. Learn the mechanism, clinical severity, monitoring steps, and dose adjustments from primary medical evidence.
Losartan and Diphenhydramine Interaction: What You Need to Know
A clinician-level review of the losartan and diphenhydramine drug interaction: pharmacokinetic and pharmacodynamic mechanisms, severity, monitoring, dose considerations, and patient counseling.
Losartan and Finasteride Interaction: What Patients and Clinicians Need to Know
A guide to the losartan and finasteride drug interaction, covering mechanism, blood pressure effects, sexual side effects, monitoring protocols, and dose-adjustment strategies.
Losartan and Gabapentin Interaction: Safety, Risks, and Clinical Guidance
Does losartan interact with gabapentin? What is established about the pharmacokinetic and pharmacodynamic profile, what remains unverified, and what to monitor if the two are prescribed together.
Losartan and Hormonal Contraceptives: Drug Interaction, Risks, and Safer Alternatives
Board-reviewed guide to the losartan and hormonal contraceptives interaction, covering CYP metabolism overlap, estrogen-driven blood pressure effects, guideline recommendations, and progestin-only alternatives.
Losartan and Metformin Interaction: Safety, Risks, and Monitoring
Can you take losartan with metformin? A guide to the pharmacokinetic and pharmacodynamic interaction between losartan and metformin, including renal monitoring, dose adjustments, and clinical evidence.
Losartan and NSAIDs (Ibuprofen, Naproxen) Interaction: Risks, Monitoring, and Safer Alternatives
Clinical guide to the losartan-NSAID interaction covering mechanism, renal risk, blood pressure blunting, hyperkalemia, monitoring protocols, and safer analgesic alternatives.
Losartan and Opioids (Oxycodone, Hydrocodone, Tramadol): Interaction Risk, Mechanism, and Monitoring
Clinical guide to combining losartan with opioids including oxycodone, hydrocodone, and tramadol. Covers CYP-mediated pharmacokinetic overlap, additive hypotension risk, renal monitoring, and what remains unverified.
Losartan and PPIs (Omeprazole, Pantoprazole): Drug Interaction Explained
A source-audited guide to the losartan-PPI interaction: the CYP2C9 mechanism, what is established versus plausible, and what to verify before assuming clinical significance.
Losartan and Prednisone Interaction: Risks, Monitoring, and Clinical Guidance
A guide to the losartan and prednisone drug interaction, covering blood pressure effects, kidney risks, electrolyte changes, and evidence-based monitoring protocols.
Losartan and Pregabalin Interaction: What Patients and Clinicians Need to Know
A complete clinical guide to the losartan and pregabalin drug interaction, covering pharmacodynamic mechanisms, sedation and hypotension risks, monitoring parameters, dose considerations, and patient counseling points backed by primary literature.
Losartan and Progesterone HRT Interaction: What Patients and Clinicians Need to Know
A clinical review of the losartan and progesterone HRT interaction, covering plausible mechanisms, what has and has not been directly studied, monitoring parameters, and patient counseling points, with an explicit map of evidence strength.
Losartan and Rivaroxaban Interaction: Safety, Risks, and Monitoring
Can you take losartan with rivaroxaban? A review of the pharmacodynamic interaction between losartan and rivaroxaban, including bleeding risk, renal monitoring, and what still needs verification.
Losartan and Rosuvastatin Interaction: What Patients and Clinicians Need to Know
Losartan and rosuvastatin can generally be taken together, since they share no CYP interaction. The main concern is renal monitoring in kidney disease.
Losartan and Sildenafil Interaction: Safety, Risks, and Clinical Guidance
Can you take losartan with sildenafil? Learn about the pharmacodynamic interaction, blood pressure effects, monitoring recommendations, and dose adjustments backed by clinical evidence.
Losartan and Simvastatin Interaction: Safety, Risks, and What Your Doctor Monitors
Can you take losartan with simvastatin? A guide covering the pharmacokinetic interaction, CYP3A4 metabolism, monitoring requirements, and dose considerations.
Losartan and SSRIs (Sertraline, Escitalopram): Drug Interaction Guide
Can you take losartan with SSRIs like sertraline or escitalopram? A guide covering mechanism, severity, monitoring, dose adjustment, and patient counseling.
Losartan and Tadalafil Interaction: Safety, Risks, and Clinical Guidance
Can you take losartan with tadalafil? A guide covering the pharmacodynamic interaction, blood pressure monitoring, dose adjustments, and real-world safety data for this common drug combination.
Losartan and Testosterone Interaction: What Patients and Clinicians Need to Know
A clinical deep-dive into the losartan and testosterone interaction, covering CYP2C9 pharmacokinetics, blood pressure effects, polycythemia risk, lipid changes, and monitoring protocols for men on TRT.
Losartan and Zolpidem Interaction: Safety, Risks, and Clinical Guidance
Can you take losartan with zolpidem? A guide to the pharmacokinetic and pharmacodynamic interaction between losartan and zolpidem, what is established versus plausible but unproven, and what to monitor.