20 source-based articles maintained by the HealthRX.com Editorial Team.
Showing 20 of 20 clinical reviews.
Modafinil induces CYP3A4, which can lower atorvastatin blood levels and reduce statin efficacy. Learn the mechanism, clinical significance, monitoring plan, and alternative statin options.
Modafinil (Provigil) may reduce hormonal contraceptive efficacy through CYP3A4 induction. What the FDA label says, what pharmacokinetic data show, and how to counsel patients on backup contraception.
Clinical guide to the modafinil-bupropion drug interaction covering CYP enzyme effects, seizure threshold concerns, dose adjustments, and physician monitoring protocols.
How modafinil and finasteride may interact, what the drug labels and human interaction study show, and how to review hair, urinary, and PSA changes.
Is it safe to take Provigil (modafinil) with metformin? A guide covering CYP enzyme interactions, blood glucose effects, monitoring protocols, and dose-adjustment considerations.
Can you take Provigil with ibuprofen or naproxen? A breakdown of the modafinil-NSAID interaction, covering CYP metabolism, GI risk, renal concerns, and dose-adjustment guidance.
A guide to the modafinil-prednisone drug interaction, covering CYP3A4 induction, reduced steroid exposure, glucose effects, and clinical monitoring.
Board-reviewed guide to the modafinil-pregabalin drug interaction covering CYP pharmacokinetics, pharmacodynamic CNS effects, monitoring, dose adjustment, and patient counseling.
Clinical review of modafinil interactions with SSRIs including sertraline and escitalopram. Covers CYP2C19 inhibition, serotonin syndrome risk, dose adjustment, and monitoring protocols.
Modafinil (Provigil) raises real perioperative concerns including increased anesthetic requirements, cardiovascular effects, and drug interactions with opioids and sedatives. Learn what the evidence says and what to tell your surgical team.
A clinical deep-dive into the modafinil, diphenhydramine drug interaction, covering CYP enzyme effects, pharmacodynamic opposition, severity ratings, dose adjustments, and patient counseling.
A clinical review of the modafinil-levothyroxine drug interaction covering CYP3A4 induction, absorption timing, TSH monitoring, and dose-adjustment protocols.
A clinician-level guide to the modafinil, opioid drug interaction covering CYP3A4 induction, pharmacodynamic CNS effects, tramadol-specific seizure risk, dose-adjustment, and monitoring for oxycodone, hydrocodone, and tramadol.
A clinician-oriented review of the modafinil and PPI (omeprazole, pantoprazole) drug interaction: mechanism, evidence quality, monitoring, and what still needs verification.
Modafinil (Provigil) induces CYP3A4, which metabolizes progesterone. Learn how this interaction reduces hormone levels, what clinical monitoring looks like, and how prescribers manage the combination safely.
Modafinil (Provigil) and sildenafil share CYP3A4 metabolism. Learn the pharmacokinetic interaction, clinical severity, dose adjustments, and monitoring recommendations backed by FDA labeling and primary literature.
A guide to the modafinil, SNRI drug interaction, covering serotonin syndrome risk, CYP enzyme effects, blood pressure monitoring, and safe co-prescribing strategies for venlafaxine and duloxetine.
How modafinil (Provigil) and tadalafil (Cialis, Adcirca) may interact through the CYP3A4 enzyme pathway, what is established from FDA labeling versus what remains unstudied, and what to verify with a prescriber or pharmacist.
A guide to the modafinil and testosterone drug interaction, covering CYP3A4 induction, androgen pharmacokinetics, polycythemia risk, lipid effects, and clinical monitoring protocols.
A guide to the modafinil-cannabis interaction: pharmacokinetics, CNS effects, cardiovascular risks, CYP enzyme competition, and safety guidance for Provigil users who also use cannabis.