Is Modafinil a Controlled Substance? US, UK, Canada, and EU Status
Is modafinil a controlled substance or narcotic? Compare its Schedule IV status in the United States with prescription rules in the UK, Canada, and European Union.
Modafinil
17 source-based articles maintained by the HealthRX.com Editorial Team.
17articles
6topic areas covered
May 27, 2026latest review
Modafinil library
Showing 17 of 17 clinical reviews.
Modafinil (Provigil) Food & Supplement Interactions: What to Take, What to Avoid
Evidence-based guide to modafinil food and supplement interactions, including caffeine, grapefruit, St. John's wort, and timing with meals. prepared by the HealthRX.com Editorial Team.
Modafinil Interactions: Full List and Risk Levels
Modafinil induces CYP3A4 and inhibits CYP2C19, lowering birth control and cyclosporine efficacy while raising levels of omeprazole, diazepam, and phenytoin.
Modafinil Safety Signals and FDA Actions: What Clinicians and Patients Should Know
A comprehensive review of modafinil (Provigil) safety signals, FDA regulatory actions, serious dermatologic reactions, psychiatric adverse events, and the rejected pediatric indication.
Modafinil Starting Dose for Adults (200 mg Guide)
Standard adult modafinil starting dose is 200 mg each morning, up to 400 mg max. See timing for narcolepsy, shift work, OSA, and liver dose adjustments.
Provigil (Modafinil) Dosing in Renal Impairment: Evidence-Based Adjustments
How to think about modafinil dosing in patients with chronic kidney disease, including FDA label guidance, what is known about metabolite handling, dialysis considerations, and a monitoring framework. Pending qualified clinical review.
Provigil (Modafinil) Safety for Adults Aged 30 to 49
Evidence-based safety guide for modafinil (Provigil) in adults aged 30-49, covering cardiovascular risk, drug interactions, psychiatric effects, and monitoring recommendations.
Provigil Autoimmune Disease Considerations
A clinician-level review of modafinil (Provigil) use in patients with autoimmune disease, covering pharmacology, immune interactions, drug-drug interactions with immunosuppressants, and monitoring protocols.
Provigil Cardiovascular Impact Long-Term: What the Evidence Actually Shows
A deep dive into modafinil's long-term cardiovascular effects, covering blood pressure, heart rate, arrhythmia risk, and what the clinical evidence base does and does not establish in chronic users.
Provigil Cognitive Function Impact: What the Clinical Evidence Actually Shows
A deep dive into how modafinil (Provigil) affects cognitive function, covering mechanism, evidence quality by population, dosing considerations, risks, and who is most likely to benefit.
Provigil Compounded vs Branded: A Clinical Comparison of Modafinil Options
A physician-level comparison of compounded modafinil vs branded Provigil, covering FDA status, bioequivalence, cost, clinical trial data, and when each option may be appropriate.
Provigil Cost vs. Alternatives in Class: Modafinil, Armodafinil, and Beyond
A clinical comparison of Provigil (modafinil) pricing against armodafinil, pitolisant, solriamfetol, and traditional stimulants, with trial data, insurance coverage details, and practical switching guidance.
Provigil Hair and Skin Changes: What Modafinil Users and Clinicians Need to Know
A guide to modafinil (Provigil) hair and skin changes, covering telogen effluvium, serious rash reactions, seborrheic dermatitis, and evidence-based management steps.
Provigil History and Development: From French Lab to FDA-Approved Wakefulness Agent
A complete timeline of modafinil (Provigil) from its 1974 synthesis in France through FDA approval, patent battles, and current clinical use for narcolepsy and shift-work disorder.
Provigil How to Safely Stop: A Complete Modafinil Discontinuation Protocol
Learn how to safely stop modafinil (Provigil) with an evidence-based tapering protocol, withdrawal timeline, and clinical guidance from the HealthRX.com medical team.
Provigil Manufacturing, Supply & Shortage History: A Complete Timeline
A detailed history of modafinil (Provigil) manufacturing, FDA supply chain events, generic entry, and shortage timelines with clinical context and primary source citations.
Provigil Mechanism of Action: The Full Pathway Behind Modafinil
A physician-level breakdown of how modafinil (Provigil) works, covering dopamine transporter inhibition, norepinephrine reuptake, histaminergic activation, orexin signaling, and GABA-glutamate modulation with full PubMed citations.