HealthRX.com · Printable medication review sheet
Zepbound and Trulicity switch planner: doses, diagnosis and the first eight weeks
For a switch in either direction: write down the last dose of the old medicine and the label's first dose of the new one, the diagnosis your plan will need to see on the claim, and how the first eight weeks go, so each check-in starts from facts.
Which way and why
DirectionTrulicity to Zepbound, or Zepbound to Trulicity
Main reasonweight, blood sugar, side effects, plan coverage, supply
Old medicine: last dose (mg) and date given
New medicine: first dose (mg) and planned date
Who set the start dateprescriber name
Coverage before the first new pen
The two labels cover different conditions, so the claim has to match the new medicine.
- Diagnosis on the prescription matches the new medicine's labelled use
- For Zepbound: BMI and any weight-related condition are documented
- For Trulicity: type 2 diabetes diagnosis is on the claim
- Prior authorization submitted, or confirmed not needed
- Savings card or assistance program checked for the new medicine
Label points that change with the switch
- Zepbound starts at 2.5 mg once weekly for 4 weeks; 2.5 mg is a starting dose, not a maintenance dose.[1]
- Trulicity starts at 0.75 mg once weekly; after 4 weeks it may be raised to 1.5 mg.[2]
- The Zepbound label does not recommend using it together with any GLP-1 receptor agonist.[1]
- With insulin or a sulfonylurea, the Zepbound label warns of a higher risk of low blood sugar, and the Trulicity Medication Guide says the same.[1]
- A Zepbound single-dose pen or vial may be kept unrefrigerated, not above 86°F (30°C), for up to a total of 21 days.[1]
- A Trulicity pen may be kept at room temperature, not above 86°F (30°C), for a total of 14 days.[2]
First eight weeks on the new medicine
| Week | Dose (mg) | Nausea, vomiting or diarrhea | Appetite | Weight or glucose | Questions for the check-in |
|---|---|---|---|---|---|
| 1 | |||||
| 2 | |||||
| 3 | |||||
| 4 | |||||
| 5 | |||||
| 6 | |||||
| 7 | |||||
| 8 |
Call rather than wait for the check-in
- Severe pain in your stomach area that will not go away, with or without nausea or vomiting: stop the medicine and call your healthcare provider right away.[2]
- Nausea, vomiting or diarrhea that does not go away: tell your healthcare provider right away.[2]
Sources for the facts on this sheet
- Eli Lilly and Company, via DailyMed. Zepbound (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-28. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b
- Eli Lilly and Company, via DailyMed. Trulicity (dulaglutide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-06-16. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=463050bd-2b1c-40f5-b3c3-0a04bb433309
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.