HealthRX.com · Printable medication review sheet
Mounjaro and SNRI check-in record: nausea, blood pressure and other serotonergic medicines
Use this when Mounjaro and duloxetine or venlafaxine overlap, especially while either dose is changing. It keeps both prescribers' information on one page: how and when you take each medicine, a log of nausea and blood pressure, other medicines that add serotonin effects, and the warning signs in each label.
Your two medicines
SNRI and formduloxetine delayed-release, venlafaxine XR, venlafaxine tablets
SNRI dose, time of day, with or without food
Mounjaro dose and injection day
Date either dose last changed
Who prescribes each
Other medicines that add serotonin effects
Tick any you take or have been offered, and show this list to both prescribers.
- A triptan for migraine
- Tramadol, fentanyl, meperidine or methadone
- Another antidepressant, including a tricyclic
- Lithium
- Buspirone
- An amphetamine
- Tryptophan or St. John's wort
Check-in log
Change one medicine at a time where your prescribers agree, and log a few days after each change.
| Date | Mounjaro dose | SNRI dose | Nausea (none, mild, moderate, severe) | Vomiting | Blood pressure | Dizzy on standing? | Notes |
|---|---|---|---|---|---|---|---|
From the three labels
- Duloxetine's pooled adult placebo-controlled trials: nausea in 23% against 7% on placebo.[1]
- Venlafaxine XR's placebo-controlled trials: nausea in 30.0% against 11.8% on placebo.[2]
- Mounjaro's placebo-controlled diabetes trials: nausea in 12% to 18% against 4% on placebo.[3]
- Duloxetine capsules can be taken with or without food.[1]
- Venlafaxine XR is taken once a day with food, at about the same time each day.[2]
- Mounjaro delays stomach emptying and can affect how oral medicines are absorbed.[3]
- Older adults may be at greater risk of low sodium (hyponatremia) with SNRIs.[1]
Get medical help promptly
- Agitation, confusion, fast heartbeat, sweating, fever, tremor, muscle stiffness or twitching, with or without nausea or diarrhea (possible serotonin syndrome).[1]
- Headache, trouble concentrating, confusion, weakness or unsteadiness (possible low sodium).[1]
- Severe stomach pain that will not go away, sometimes spreading to the back.[3]
Questions for either prescriber
- Should we change only one of these medicines at a time?
- Does my blood pressure need checking more often while both doses are changing?
- Would a sodium blood test be sensible for me?
- Does my SNRI form or timing matter now that my stomach empties more slowly?
- Who should I call first if nausea stops me eating or drinking?
Sources for the facts on this sheet
- Solco Healthcare US, LLC, via DailyMed. Duloxetine delayed-release capsules, for oral use: prescribing information and Medication Guide. Effective 2025-12-21. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a105a648-6a97-4151-b9de-d7eac90a8f79
- Viatris Specialty LLC, via DailyMed. Effexor XR (venlafaxine extended-release) capsules, for oral use: prescribing information and Medication Guide. Effective 2023-08-15. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c848a5d8-ba94-4c84-80e3-0bf35fb8e32e
- Eli Lilly and Company, via DailyMed. Mounjaro (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-27. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.