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HealthRX.com · Printable medication review sheet

Ozempic with atorvastatin: pharmacist check card

Bring this to a pharmacist or prescriber review: your atorvastatin dose and timing, any medicine on the label's list that raises atorvastatin levels, and the muscle or liver symptoms the Lipitor guide says to report. It also keeps the measured semaglutide result in view.

Companion to “Ozempic and Atorvastatin Interaction: What You Need to Know” · healthrx.com/interactions-ozempic/with-atorvastatin · Facts checked 2026-10-19

The two medicines

Atorvastatin dose (mg) and the time you take it
Ozempic dose and injection day
Who prescribes each
Last LDL cholesterol result and date
Any recent change to either dose

Tick anything else you take: the Lipitor label lists these as raising atorvastatin levels or myopathy risk

  • Clarithromycin or erythromycin (antibiotics)
  • Itraconazole, ketoconazole, posaconazole or voriconazole (antifungals)
  • Cyclosporine
  • Gemfibrozil or another fibrate
  • An HIV or hepatitis C antiviral
  • Colchicine or niacin
  • Large amounts of grapefruit juice

What the study and the labels say

  • With semaglutide 1 mg at steady state, a single 40 mg atorvastatin dose gave the same total exposure (ratio 1.02) but a lower, later peak (ratio 0.62; median 2.0 vs 0.7 hours).[1]
  • Lipitor label: food lowers the peak by about 25% and total exposure by about 9%, and LDL-C lowering is similar with or without food.[2]
  • Lipitor label: evening doses give about 30% lower levels than morning doses, with the same LDL-C reduction.[2]
  • Lipitor label: with clarithromycin or itraconazole, do not exceed 20 mg once daily; cyclosporine or gemfibrozil with Lipitor is not recommended; avoid more than 1.2 liters of grapefruit juice a day.[2]
  • Ozempic label: Ozempic delays gastric emptying and may affect how oral medicines taken with it are absorbed.[3]

Contact your healthcare provider right away

  • Unexplained muscle pain, tenderness or weakness, especially with a fever or feeling more tired than usual (Lipitor guide: tell your provider right away).[2]
  • Liver warning signs: feeling tired or weak, nausea or vomiting, loss of appetite, upper belly pain, dark amber urine, or yellow skin or eyes (Lipitor guide: call right away).[2]
  • Severe stomach pain that will not go away, with or without vomiting (Ozempic guide: stop Ozempic and call right away).[3]

Questions for the review

  1. Is my LDL cholesterol at the goal set for me on this atorvastatin dose?
  2. Do any of my antibiotics, antifungals or other medicines change the atorvastatin dose I can take?
  3. Does the time of day I take atorvastatin matter while my Ozempic dose is going up?
  4. If vomiting stops me keeping tablets down, what should I do about atorvastatin?
  5. When should my next lipid panel be?
Sources for the facts on this sheet
  1. Hausner H, Derving Karsbøl J, Holst AG, et al. Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects. Clin Pharmacokinet 2017. PMID 28349387. https://pubmed.ncbi.nlm.nih.gov/28349387/
  2. Viatris Specialty LLC, via DailyMed. Lipitor (atorvastatin calcium) tablets, for oral use: prescribing information and patient information. Effective 2024-04-15. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a60cc18b-0631-4cf0-b021-9f52224ece65
  3. Novo Nordisk, via DailyMed. Ozempic (semaglutide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-06-01. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.