HealthRX.com · Printable medication review sheet
Wegovy and PPI review: is the acid reducer still needed?
Write down why and since when you take a PPI, track heartburn and stomach symptoms at each Wegovy dose step and as weight changes, and bring the questions about stepping down and about magnesium or B12 checks to your next visit.
Your acid reducer
PPI name and doseomeprazole, pantoprazole, other
When it was started, and whyheartburn, erosive esophagitis seen on endoscopy, ulcer, other
When you take ithow many minutes before which meal
Ever tried a lower dose or stopping? What happened?
Wegovy dose now, and weight now versus at the start
Reflux check at each Wegovy dose step
Fill in one line a week. A change right after a Wegovy dose increase points to the dose step; a slow improvement as weight falls is the trend to discuss before any step-down.
| Week | Wegovy dose | Days with heartburn | Regurgitation or sour taste | Nausea or bloating | PPI doses missed | Weight |
|---|---|---|---|---|---|---|
What the omeprazole and Wegovy labels say
- Heartburn from GERD: omeprazole 20 mg once daily for up to 4 weeks.[1]
- Erosive esophagitis: 20 mg once daily for 4 to 8 weeks; benefit of longer than 8 weeks for healing has not been established.[1]
- Low magnesium has been reported after at least three months of PPI use, in most cases after a year.[1]
- Daily long-term use, for example longer than 3 years, can lead to low vitamin B12.[1]
- Fracture risk rose with multiple daily doses taken for a year or longer.[1]
- In the Wegovy tablet studies, omeprazole did not change semaglutide levels in a clinically significant way.[2]
Questions about stepping down
- Is my PPI still needed at this dose now that my weight has changed?
- Would a lower dose or on-demand use suit me, and how would we judge whether it works?
- Given how long I have taken a PPI, should magnesium or vitamin B12 be checked?
- If reflux gets worse right after a Wegovy dose increase, how do we tell that apart from the PPI not working?
- Do I need an endoscopy before any change, given why the PPI was started?
Call right away for
- Watery stools or stomach pain that does not go away while on a PPI.[1]
- Severe pain in the stomach area that will not go away, with or without nausea or vomiting: stop Wegovy and call your healthcare provider.[2]
Sources for the facts on this sheet
- Covis Pharma US, via DailyMed. Prilosec (omeprazole magnesium) for delayed-release oral suspension: prescribing information. Effective 2024-03-19. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b6761f84-53ac-4745-a8c8-1e5427d7e179
- Novo Nordisk, via DailyMed. Wegovy (semaglutide) injection, for subcutaneous use, and Wegovy (semaglutide) tablets, for oral use: prescribing information and Medication Guide. Effective 2026-06-18. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ee06186f-2aa3-4990-a760-757579d8f77b
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.