HealthRX.com · Printable medication review sheet
Clopidogrel and Zepbound medicine review for your heart and prescribing teams
Bring this to cardiology, the Zepbound prescriber or the pharmacist: why you take clopidogrel and since when, your CYP2C19 result if tested, the other medicines that change clopidogrel, each Zepbound dose change, and the bleeding signs from the Plavix Medication Guide that need a same-day call.
Why you take clopidogrel
Reasonstent, heart attack, stroke, peripheral artery disease
Date of the stent or event
Planned length of clopidogrel treatment
Aspirin, another antiplatelet or an anticoagulant as well?
CYP2C19 genetic testnot done / result
Medicines and products to list for the pharmacist
- Omeprazole (Prilosec) or esomeprazole (Nexium)
- Opioid pain medicines, including after a procedure
- Ibuprofen, naproxen or other anti-inflammatory pain relievers
- Warfarin or another anticoagulant
- Repaglinide or other diabetes medicines
- Zepbound: current dose and injection day
Zepbound dose changes
| Date | Zepbound dose (mg) | Clopidogrel taken every day? | Bruising or bleeding | Notes from the care team |
|---|---|---|---|---|
From the labels
- Plavix: avoid omeprazole and esomeprazole, because both significantly reduce clopidogrel's antiplatelet effect.[1]
- Plavix: opioids delay and reduce clopidogrel absorption, presumably by slowing stomach emptying.[1]
- Plavix: about 2% of White and 4% of Black patients are CYP2C19 poor metabolizers, and more Asian patients (for example 14% of Chinese patients); tests can identify them.[1]
- Plavix: stopping early raises the risk of heart and blood vessel events; for elective surgery with a major bleeding risk the label says stop 5 days before.[1]
- Zepbound: oral medicines that depend on reaching a threshold level to work should be monitored when Zepbound is added.[2]
Call your doctor right away (Plavix Medication Guide)
- Unexpected bleeding, or bleeding that lasts a long time.[1]
- Pink, red or brown urine, or red or black stools that look like tar.[1]
- Bruises with no known cause or that get larger, coughing up blood, or vomiting blood.[1]
Questions for cardiology or the pharmacist
- Is clopidogrel still the right antiplatelet for me, or would another suit me better?
- Should my CYP2C19 status be tested?
- Do you want any platelet testing while my Zepbound dose is going up?
- If Zepbound gives me reflux, which acid reducer is safe with clopidogrel?
- Before a procedure, who decides what happens to each medicine?
Sources for the facts on this sheet
- sanofi-aventis U.S. LLC, via DailyMed. Plavix (clopidogrel tablets) for oral use: prescribing information and Medication Guide. Effective 2025-05-30. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de8b0b67-eb25-4684-83b5-7ad785314227
- Eli Lilly and Company, via DailyMed. Zepbound (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-28. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.