HealthRX.com · Printable medication review sheet
Zepbound and progesterone medication review
A one-page record for the clinician who manages your hormone therapy: which progesterone you take and by what route, your Zepbound start and dose-increase dates, any vomiting after oral doses or new bleeding, and the label facts that apply to each.
Your hormone therapy now
Progesterone product and strengthoral capsule, vaginal insert or gel, or injection
How you take itby mouth, vaginally or by injection
Scheduleevery night, or set days in each cycle
Time of day, and with or without food
Estrogen product, dose and routepatch, gel, spray, pill or vaginal
Clinician who prescribes your hormone therapy
Your Zepbound timeline
Date you started Zepbound
Current weekly dose (mg) and injection day
Dates of each dose increase
Clinician who prescribes Zepbound
Weeks after starting or increasing Zepbound
One line per week, or per event. Note the date of any vomiting and how long after an oral progesterone dose it happened.
| Date | Zepbound dose (mg) | Progesterone dose taken or missed | Vomited after an oral dose? When? | Spotting or bleeding | Other symptoms |
|---|---|---|---|---|---|
What the two labels say
- Zepbound slows stomach emptying and may affect the absorption of medicines taken by mouth at the same time.[1]
- In the Zepbound label's study, a first 5 mg dose lowered oral contraceptive hormone peaks by 55% to 66% and total exposure by 20% to 23%.[1]
- For contraceptive pills, the Zepbound label advises switching to a non-oral method, or adding a barrier method, for 4 weeks after starting and for 4 weeks after each dose increase. Hormonal contraceptives not taken by mouth should not be affected.[1]
- Prometrium is taken as one dose at bedtime. Blood levels peak within 3 hours, and food increases absorption compared with an empty stomach.[2]
- To protect the womb lining, the Prometrium label dose is 200 mg at bedtime for 12 days of each 28-day cycle, alongside daily conjugated estrogens.[2]
Contact a clinician promptly
- Unusual vaginal bleeding while taking progesterone.[2]
- Severe stomach pain that will not go away, with or without nausea or vomiting: stop Zepbound and call your healthcare provider right away.[1]
- Vomiting or diarrhea that stops you keeping fluids down: loss of fluids can cause kidney problems.[1]
Questions for your prescriber
- Is my current progesterone route still the best fit now that I take Zepbound?
- Does anything need to change in the weeks after I start Zepbound or increase the dose?
- If I vomit soon after an oral progesterone dose, should I take another or wait for the next one?
- What bleeding pattern should I expect on my regimen, and what should I report?
- As my weight changes, when should we review my estrogen dose and the rest of the regimen?
Sources for the facts on this sheet
- Eli Lilly and Company, via DailyMed. Zepbound (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-28. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b
- Acertis Pharmaceuticals, LLC, via DailyMed. Prometrium (progesterone, USP) capsules: prescribing information and patient information. Effective 2026-07-23. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1cf237ff-c4f8-4faa-a7aa-77599c856889
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.