HealthRX.com · Printable lab tracker
Kidney check and pregabalin dose tracker
Record your kidney results, any days of vomiting or diarrhea, and your pregabalin dose while Zepbound is started and increased, with the label's dose ranges by creatinine clearance printed alongside for your prescriber.
Pregabalin now
Total daily dose (mg) and how it is split
Reasonnerve pain, fibromyalgia, seizures, other
Prescriber
Baseline before Zepbound
Creatinine, with date
eGFR or creatinine clearance, with date
Weight
Kidney results and fluid losses
| Date | Zepbound dose (mg) | Creatinine | eGFR or CrCl | Days with vomiting or diarrhea | Dizzy or sleepy? | Pregabalin dose changed? |
|---|---|---|---|---|---|---|
Label dose ranges by kidney function[1]
For reference only; your prescriber sets the dose.
| Creatinine clearance (mL/min) | Total daily dose (mg/day) | How often |
|---|---|---|
| 60 or more | 150 to 600 | twice or three times a day |
| 30 to 60 | 75 to 300 | twice or three times a day |
| 15 to 30 | 25 to 150 | once or twice a day |
| Below 15 | 25 to 75 | once a day |
Label points
- About 90% of a pregabalin dose leaves the body unchanged in the urine.[1]
- Kidney function should be checked if Zepbound side effects could dehydrate you, especially while the dose is being started or raised.[2]
- If pregabalin is stopped, it is tapered over at least 1 week rather than stopped suddenly.[1]
- Pregabalin can cause serious breathing problems with other medicines that cause severe sleepiness, or in someone who already has breathing problems.[1]
Contact a clinician promptly for
- Nausea, vomiting or diarrhea that does not go away, or that stops you keeping fluids down.[2]
- Swelling of the face, mouth, lips, gums, tongue, throat or neck, or trouble breathing: stop pregabalin and call right away.[1]
- Unusual sleepiness or breathing difficulty, especially with an opioid or another sedating medicine.[1]
Questions for your prescriber
- How often should my kidney function be checked while Zepbound is increased?
- Would my pregabalin dose change if my creatinine clearance dropped?
- Is my pregabalin dose the lowest that controls my symptoms, given its effect on weight?
- If I take pregabalin for seizures and vomit soon after a dose, what should I do?
Sources for the facts on this sheet
- Viatris Specialty LLC, via DailyMed. Lyrica (pregabalin) capsules and oral solution: prescribing information and Medication Guide. Effective 2025-04-15. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d4734e7d-5079-455e-8ff5-8f4539c998a9
- Eli Lilly and Company, via DailyMed. Zepbound (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-28. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.