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HealthRX.com · Printable lab tracker

Rosuvastatin and Zepbound lab and symptom tracker

Log lipid, CK and liver results with your rosuvastatin and Zepbound doses and any muscle symptoms, so a rise in LDL-C or a new ache can be judged against the label's timing and risk factors rather than guessed at.

Companion to “Zepbound and Rosuvastatin Interaction: Safety, Mechanism, and Clinical Guidance” · healthrx.com/interactions-zepbound/with-rosuvastatin · Facts checked 2026-10-18

Before the first Zepbound dose

Rosuvastatin dose (mg) and time of day
LDL-C, with date
CK and ALT, with dates
Other cholesterol medicinesezetimibe, a fibrate, other

Results over time

One row per blood test or new symptom.

DateZepbound dose (mg)Rosuvastatin dose (mg)LDL-CCKALTWeightMuscle symptoms

Rosuvastatin label points

  • Take it once a day at any time of day, with or without food.[1]
  • If a dose is missed, do not take an extra one; go back to the usual schedule.[1]
  • LDL-C can be checked as early as 4 weeks after starting rosuvastatin.[1]
  • Blood levels peak 3 to 5 hours after a dose, and the half-life is about 19 hours.[1]
  • Age 65 or older, uncontrolled hypothyroidism and kidney impairment raise the risk of muscle problems.[1]
  • Vomiting, diarrhea and nausea on Zepbound can cause dehydration and kidney problems.[2]

Report promptly

  • Unexplained muscle pain, tenderness or weakness, especially with fever or feeling unwell.[1]
  • Unusual tiredness, loss of appetite, pain under the right ribs, dark urine or yellowing of the skin or eyes.[1]
  • Nausea, vomiting or diarrhea that does not go away.[2]

To settle with your prescriber

  1. When should my next lipid panel be, now that Zepbound has started?
  2. If my LDL-C rises, will we check adherence and diet first, or add a non-statin medicine such as ezetimibe?
  3. Should CK be checked if I get muscle aches while losing weight?
  4. Does my rosuvastatin dose need review if my kidney function changes?
Sources for the facts on this sheet
  1. AstraZeneca Pharmaceuticals LP, via DailyMed. Crestor (rosuvastatin) tablets: prescribing information and patient information. Effective 2026-09-23. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=325a5d0e-9a72-4015-9fcd-1655fb504cee
  2. Eli Lilly and Company, via DailyMed. Zepbound (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-28. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.