HealthRX.com · Printable training log
MOTS-c performance-claim check and training record
Use this sheet when a seller, coach or video says MOTS-c will improve your training. Write the claim down, test the study behind it against this page's seven questions, and keep your own training record as the evidence you judge progress by.
The claim you are checking
Where you saw itseller, coach, video, forum
Exact words of the claim
Outcome promisedspeed, endurance, strength, recovery, body composition
Study cited, if anyauthor, year, journal or PMID
Test the cited study
These are the questions in this page's training-claim record. A claim that fails the first three is not human performance evidence.
| Question | What the study actually did | Passes? |
|---|---|---|
| Was MOTS-c measured in the body or given as a treatment? | ||
| Was it done in people, animals or cells? | ||
| What outcome was measured? | ||
| Was there randomization and a placebo group? | ||
| Was the tested material characterized? | ||
| Are results reported, or is the study only registered? | ||
| What result would change the conclusion? |
Where the published evidence stands
- In people, studies measured the body's own MOTS-c: in 10 young men, muscle levels rose 11.9-fold after one cycling session.[1]
- Performance gains after giving MOTS-c come from mice: one dose raised running time 12% and distance 15% in untrained mice.[2]
- The registered human trial NCT07505745 tests insulin sensitivity over 12 weeks in adults with prediabetes, not exercise performance.[3]
- FDA says it has not identified human exposure data for drug products containing MOTS-c, and flags possible immunogenicity and impurity problems in compounded versions.[4]
Your training record
Exercise itself has the human evidence. Judge progress by what you can measure in your own training.
| Date | Session (type and length) | Measure you track (time, distance or load) | Sleep and soreness | Notes |
|---|---|---|---|---|
Questions for whoever makes the claim
- Which human study gave MOTS-c and measured this outcome?
- Was it randomized and placebo-controlled, and how many people took part?
- Are the results published, or is the trial only registered?
- Who tested this product's identity, purity, sterility and potency, and can I see the report?
- What harms were tracked, and for how long after the last dose?
Sources for the facts on this sheet
- Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun 2021. PMID 33473109. https://pubmed.ncbi.nlm.nih.gov/33473109/
- Hyatt JK. MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose. Physiol Rep 2022. PMID 35808870. https://pubmed.ncbi.nlm.nih.gov/35808870/
- U.S. National Library of Medicine, ClinicalTrials.gov (API v2 record). NCT07505745: A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of MOTS-c (a Mitochondrial-Derived Peptide) in Adults With Prediabetes and Overweight/Obesity. Accessed 2026-10-17. https://clinicaltrials.gov/api/v2/studies/NCT07505745
- U.S. Food and Drug Administration. Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks. Accessed 2026-10-17. https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.