HealthRX.com · Printable supplement log
NMN or NR supplement log: what you take, how you feel, when to stop
Write down the product and the daily amount you actually take, check in once a week for the stomach symptoms the trials tracked, and keep your lab results on the same sheet. The stop and reassess points come from this page; bring the log to whoever orders your labs.
What you are taking
Copy the amounts from the product label, not from an ad. Write NMN or NR exactly as the label names it.
What the trials gave (research doses, not your prescription)
- Yoshino et al.: 250 mg of NMN a day for 10 weeks in women with prediabetes; no adverse events were reported.[1]
- Yi et al.: 300, 600 or 900 mg of NMN a day for 60 days in healthy middle-aged adults; no safety issues were found.[2]
- Conze et al.: 100, 300 or 1,000 mg of NR a day for 8 weeks; no flushing, and adverse events no different from placebo.[3]
- Martens et al.: 500 mg of NR twice a day for 6 weeks; no serious adverse events.[4]
Weekly check-in
One line a week. Stomach symptoms were the most common complaints in the trials this page reviews.
| Week | Daily amount (mg) | Days missed | Nausea, bloating or diarrhea | Flushing | Sleep | Anything else new |
|---|---|---|---|---|---|---|
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| 12 |
Lab results
The page suggests a baseline metabolic panel before starting and a reassessment by week 12.
| Test | Baseline date and result | Follow-up date and result | Lab's normal range |
|---|---|---|---|
| Liver enzymes (ALT, AST) | |||
| Kidney function (creatinine, eGFR) | |||
| Fasting insulin and HbA1c, if a metabolic goal | |||
| Whole-blood NAD+, if your clinician orders it |
Stop and talk to your clinician if
These are the stop points this page lists. Stopping NMN or NR abruptly is not known to cause withdrawal effects.
- Nausea, stomach discomfort or diarrhea that keeps going for more than 10 days
- ALT or AST above 2 times the upper limit of normal with no other explanation
- A new cancer diagnosis (tell your oncologist what you take)
- Week 12 with no change you can measure: ask whether to continue at all
Questions for your clinician
- I have had cancer. Should I take an NAD+ precursor at all?
- Which labs should we check before I start, and when should we repeat them?
- Is a blood NAD+ test worth paying for, and which lab runs it?
- I take niacin or another cholesterol medicine. Does that change anything?
- If I add resveratrol, TMG or CoQ10 later, how far apart should I start them?
- Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science 2021. PMID 33888596. https://pubmed.ncbi.nlm.nih.gov/33888596/
- Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience 2023. PMID 36482258. https://pubmed.ncbi.nlm.nih.gov/36482258/
- Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep 2019. PMID 31278280. https://pubmed.ncbi.nlm.nih.gov/31278280/
- Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018. PMID 29599478. https://pubmed.ncbi.nlm.nih.gov/29599478/
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.