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HealthRX.com · Printable medication review sheet

Adults 30 to 49 starting NMN or NR: product, plans and medicine check

A one-page check to fill in before you start and to bring to your clinician: the product you chose, life plans and medicines that change the picture at this age, and an 8-week symptom record. The trial facts are the ones charted on this page.

Companion to “NMN and NR Safety for Adults 30 to 49: What the Clinical Evidence Shows” · healthrx.com/nad-nmn/adult-safety · Facts checked 2026-10-19

What the trials that included your age group found

  • NMN 1,250 mg once daily for up to 4 weeks in 31 adults aged 20 to 65: no severe adverse events.[1]
  • NMN up to 900 mg daily for 60 days in adults aged 40 to 65: no safety issues in adverse events, lab tests or clinical measures.[2]
  • NR up to 1,000 mg daily for 8 weeks in adults aged 40 to 60: no serious adverse events and no flushing.[3]
  • NR 2,000 mg a day for 12 weeks in men with obesity aged 40 to 70 appeared safe, but did not improve insulin sensitivity.[4]

The product you chose

Product name and seller
NMN or NR, and amount per serving
Servings per day you plan to take
Independent test certificatelab name and date, or none
Start date

Tell your clinician before starting if any of these apply

  • You are pregnant, trying to conceive or breastfeeding
  • You take medicine for blood sugar, blood pressure or cholesterol
  • You are being treated for cancer, or have a strong family history
  • You drink alcohol most days
  • You already take niacin, nicotinamide or another vitamin B3 product
  • You plan to keep taking it for years, not weeks

First 8 weeks

WeekAmount takenStomach symptomsHeadache, rash or other new symptomDays missedNotes for your clinician

Questions to ask

  1. Do you want any blood tests before I start, and when should they be repeated?
  2. Could NMN or NR change how any of my current medicines work?
  3. How long should I take it before we decide whether it is doing anything for me?
  4. What symptoms would mean I should stop?
Sources for the facts on this sheet
  1. Fukamizu Y, Uchida Y, Shigekawa A, et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Sci Rep 2022. PMID 36002548. https://pubmed.ncbi.nlm.nih.gov/36002548/
  2. Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience 2023. PMID 36482258. https://pubmed.ncbi.nlm.nih.gov/36482258/
  3. Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep 2019. PMID 31278280. https://pubmed.ncbi.nlm.nih.gov/31278280/
  4. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018. PMID 29992272. https://pubmed.ncbi.nlm.nih.gov/29992272/

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.