HealthRX.com · Printable lab tracker
PCOS on tirzepatide: period, hormone and metabolic lab tracker
Use this to follow the measures this page names for PCOS: labs at baseline, 12 and 24 weeks, the start date of each period, weight and dose, and your contraception and pregnancy plans. The facts box keeps what the two trials and the Mounjaro label actually report.
Starting point
Why tirzepatide was prescribedtype 2 diabetes, a weight-related condition, other
Start date and starting dose
Starting weight
Usual gap between periods before starting
Contraception now
Plans for pregnancy
Lab results
The page suggests rechecking at about 12 and 24 weeks; your clinician may choose different tests.
| Test | Baseline | Week 12 | Week 24 | Notes |
|---|---|---|---|---|
| Fasting insulin | ||||
| Fasting glucose | ||||
| HbA1c | ||||
| Total testosterone | ||||
| Free testosterone or free androgen index | ||||
| SHBG | ||||
| DHEA-S | ||||
| Lipid panel | ||||
| ALT and AST | ||||
| Pregnancy test |
Periods, weight and dose
| Period start date | Days since the last one | Weight | Weekly dose (mg) | Notes |
|---|---|---|---|---|
What the evidence on this page shows
- In a 16-week randomized trial, adding tirzepatide 5 mg weekly to metformin brought back regular cycles in 53.6% of women, against 21.4% on metformin alone.[1]
- The same trial found no significant difference between the groups in SHBG or free androgen index.[1]
- Liraglutide 3 mg, a GLP-1 drug, lowered weight by 5.7% over 32 weeks in women with PCOS, against 1.4% on placebo.[2]
- Mounjaro may make birth control pills less effective: switch to a non-oral method or add a barrier method for 4 weeks after starting and for 4 weeks after each dose increase.[3]
- Tell your prescriber if you are pregnant or intend to become pregnant.[3]
Questions for the visit
- Which result would show that tirzepatide is helping my PCOS, not only my weight?
- Should free testosterone and SHBG be repeated, and when?
- Which contraception suits me while my dose is still going up?
- If my periods become regular, when could I start trying to conceive, and when would tirzepatide stop?
- Does metformin stay in my plan?
- Will my plan cover tirzepatide for my diagnosis?
Sources for the facts on this sheet
- Yang Z, Xu Y, Du H, et al. Short-Term Combined Treatment With Tirzepatide and Metformin for Overweight/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open-Label, Randomised Controlled Trial. Diabetes Obes Metab 2026. PMID 42236268. https://pubmed.ncbi.nlm.nih.gov/42236268/
- Elkind-Hirsch KE, Chappell N, Shaler D, et al. Liraglutide 3 mg on weight, body composition, and hormonal and metabolic parameters in women with obesity and polycystic ovary syndrome: a randomized placebo-controlled-phase 3 study. Fertil Steril 2022. PMID 35710599. https://pubmed.ncbi.nlm.nih.gov/35710599/
- Eli Lilly and Company, via DailyMed. Mounjaro (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-27. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.