HealthRX.com · Printable medication review sheet
Rybelsus switch planning sheet
Fill this in with your prescriber before changing between Rybelsus, Ozempic tablets and Ozempic injections: what you take now, the switch the label allows, your start dates, and glucose and side effects in the first weeks.
What you take now
Product, strength and formRybelsus tablet, Ozempic tablet, Ozempic injection, other GLP-1
Days or weeks on this dose
Date of the last injection, if switching from Ozempic injection
New product and strength
Start date for the new product
Label conversion between the two tablet products[1]
| Rybelsus | Ozempic tablets | When allowed |
|---|---|---|
| 7 mg once daily | 4 mg once daily | after day 30; start the day after the last old tablet |
| 14 mg once daily | 9 mg once daily | after day 30; start the day after the last old tablet |
Other label points for a switch
- From the Ozempic 0.5 mg injection only: start tablets one week after the last injection (Rybelsus 7 or 14 mg, or Ozempic tablets 4 or 9 mg).[1]
- Tablet strengths are not interchangeable mg for mg.[1]
- Omeprazole caused no clinically significant change in semaglutide levels.[1]
- Total thyroxine exposure rose by 33% when a single levothyroxine dose was taken with semaglutide tablets.[1]
- After the tablet, wait at least 30 minutes before food, drinks or other oral medicines.[1]
First weeks after switching
| Date | Product and dose | Fasting, with up to 4 oz water? | Fasting glucose | Nausea or other effects |
|---|---|---|---|---|
Questions for the prescriber
- Is my current dose one the label allows me to switch from?
- Which tablet strength do I start, and on what date?
- Should my thyroid level be checked after the switch if I take levothyroxine?
- When will we check HbA1c to see whether the switch is working?
Sources for the facts on this sheet
- Novo Nordisk, via DailyMed. Rybelsus (semaglutide) tablets and Ozempic (semaglutide) tablets, for oral use: prescribing information and Medication Guide. Effective 2026-01-30. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.