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HealthRX.com · Printable medication review sheet

Vomiting on Mounjaro: antiemetic and fluid record

Keep a record of each vomiting episode, the fluids you managed, and every antiemetic dose and its effects, then take it to your prescriber along with the background questions below. The label points for the medicines on this page and the moments to hold Mounjaro and call are printed with it.

Companion to “Medications to Manage Vomiting on Mounjaro (tirzepatide for T2D): First-Line and Beyond” · healthrx.com/side-effects-mounjaro-vomiting/medication-management · Facts checked 2026-10-18

Background your prescriber will want

Mounjaro dose and date of the last increase
Heart rhythm problem, heart failure or long QT history?
Antidepressants, opioids, sleep or anxiety medicines you take
Glaucoma, breathing problems or prostate-related urinary trouble?
Diabetes medicines that can lower blood sugarinsulin or a sulfonylurea

Episodes and doses

Date and timeTimes vomitedFluids kept downAntiemetic and doseDrowsiness or other effectsUrine: usual, less or dark

Label points for the medicines on this page

  • Ondansetron tablets: ECG monitoring is recommended with low potassium or magnesium, heart failure, slow heart rhythms or other QT-prolonging medicines, and there is a serotonin syndrome risk with other serotonergic drugs.[1]
  • Reglan (metoclopramide): in diabetic gastroparesis, avoid more than 12 weeks of treatment in total.[2]
  • Promethazine tablets: can cause marked drowsiness and impair driving or operating machinery.[3]
  • Dramamine: ask a doctor first if you have a breathing problem, glaucoma, or trouble urinating from an enlarged prostate.[4]
  • Mounjaro with insulin or a sulfonylurea raises the risk of low blood sugar, which matters on days you cannot eat.[5]

Hold the plan and call

  • Fluids not staying down, or passing much less urine: vomiting and diarrhea can cause dehydration and kidney problems.[5]
  • Persistent or severe stomach pain, sometimes spreading to the back: possible pancreatitis.[5]
  • Nausea, vomiting or diarrhea that does not go away: tell your healthcare provider right away.[5]

To agree with your prescriber

  1. Which antiemetic suits my heart history and my other medicines?
  2. Should I take it before the hours when vomiting usually starts, or only when needed?
  3. Do I need an ECG or a potassium and magnesium check first?
  4. Should my next dose increase wait, or should my dose come down?
  5. What should I do with my diabetes medicines on days I cannot eat?
Sources for the facts on this sheet
  1. Ipca Laboratories Limited, via DailyMed. Ondansetron tablets, for oral use: prescribing information. Effective 2026-07-22. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7ab3210e-eed1-479a-afc0-f72b5b776883
  2. ANI Pharmaceuticals, Inc., via DailyMed. Reglan (metoclopramide) tablets, for oral use: prescribing information. Effective 2026-02-09. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=de55c133-eb08-4a35-91a2-5dc093027397
  3. Amneal Pharmaceuticals of New York LLC, via DailyMed. Promethazine hydrochloride tablets: prescribing information. Effective 2025-12-20. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0b5734b8-6a52-44ff-ac29-9a91a4335394
  4. Medtech Products Inc., via DailyMed. Dramamine Original Formula (dimenhydrinate 50 mg) tablets: Drug Facts. Effective 2025-10-23. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f9302a5a-295a-4501-9332-e3f5eb387362
  5. Eli Lilly and Company, via DailyMed. Mounjaro (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.