HealthRX.com · Printable supplement log
Zepbound diarrhea: supplement, fluid and loperamide log
Use this while diarrhea lasts: count loose stools, note fluids and any warning signs each day, and record each supplement you try with its strain or fiber amount and what changed. The loperamide label limits and the points at which to stop self-managing are printed on the sheet.
Your situation
Zepbound dose and date of the last increase
When loose stools starteddays after an injection or a dose increase
Diuretic or SGLT2 inhibitor?name the medicine
Supplements you already takemagnesium makes diarrhea worse
Daily log
| Date | Loose stools | Blood, fever or black stool? | Fluids and rehydration drinks | Supplement and amount | Loperamide caplets taken |
|---|---|---|---|---|---|
Supplement trial record
Write the strain or fiber type and the amount printed on the label, not just the brand.
| Product, strain or fiber type | Amount on the label (CFU or grams) | Start date | Stop date | What changed |
|---|---|---|---|---|
What the evidence and labels say
- S. boulardii: in adults taking antibiotics, diarrhea fell from 17.4% to 8.2% across 15 trials. It has not been tested for diarrhea from tirzepatide.[1]
- Psyllium 10 g a day in irritable bowel syndrome, mostly constipation-predominant: adequate relief in 57% versus 35% on placebo in the first month, over a 12-week trial. It has not been tested for diarrhea from tirzepatide.[2]
- Imodium A-D label, adults and children 12 and over: 2 caplets after the first loose stool, then 1 caplet after each later loose stool, no more than 4 caplets in 24 hours.[3]
- Imodium A-D label: taking more than directed can cause serious heart problems or death.[3]
Stop self-managing and call
- Bloody or black stool: do not use loperamide. Fever or mucus in the stool: ask a doctor before using it.[3]
- Diarrhea lasting more than 2 days on loperamide, worsening symptoms, or a swollen or bulging abdomen: stop and ask a doctor.[3]
- Diarrhea that does not go away: tell your Zepbound prescriber right away, because fluid loss can cause dehydration and kidney problems.[4]
Before adding a supplement, ask
- Does my pattern fit a dose increase, or should other causes be checked?
- Should I stay at this dose longer before the next step up?
- Is a probiotic reasonable with my other conditions and medicines?
- Do I need a blood test for potassium and kidney function?
- Should I pause a magnesium supplement while this lasts?
Sources for the facts on this sheet
- Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2015. PMID 26216624. https://pubmed.ncbi.nlm.nih.gov/26216624/
- Bijkerk CJ, de Wit NJ, Muris JW, et al. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. BMJ 2009. PMID 19713235. https://pubmed.ncbi.nlm.nih.gov/19713235/
- Kenvue Brands LLC, via DailyMed. Imodium A-D (loperamide HCl 2 mg) caplets: Drug Facts. Effective 2025-09-23. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01da76d0-1979-4c45-9d39-c72ae4e4ffe2
- Eli Lilly and Company, via DailyMed. Zepbound (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-28. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.