HealthRX.com · Printable supplement log
Losartan and glutathione: product record and home blood pressure diary
Write down the exact glutathione product and how you take it, then keep home blood pressure readings from a week before you start until a few weeks after, with the times you took each one. It ends with the Cozaar warning signs that should not wait for a visit.
Your losartan
Dose (mg) and the time you usually take it
What it was prescribed forblood pressure, heart thickening, diabetic kidney disease
Other blood pressure medicines or water pills
Potassium supplement or salt substitute?yes / no, and which
Pain relievers you take oftenfor example ibuprofen or naproxen
Your glutathione product
Brand and maker
Formcapsule, liposomal, sublingual, IV or injection
mg per serving and servings per day
Other ingredients listed on the label
Start date
Home blood pressure, from a week before the supplement
Sit quietly for a few minutes first and use the same arm each time.
| Date | Time | Blood pressure | Pulse | Losartan taken at | Glutathione taken at, and mg | Dizzy or faint? |
|---|---|---|---|---|---|---|
What the Cozaar label and the glutathione studies say
- Cozaar can be taken with or without food. The label sets no spacing from supplements and does not mention glutathione.[1]
- About 14% of a losartan dose becomes its active metabolite, which peaks 3 to 4 hours after the dose.[1]
- Fluconazole, an antifungal that blocks the enzyme activating losartan, cut exposure to the active metabolite by about 40%; this is the kind of effect the label lists, and glutathione is not on its list.[1]
- The blood pressure effect is mostly present within one week, though some studies saw the full effect only at 3 to 6 weeks.[1]
- The label asks you not to use potassium supplements or potassium salt substitutes without checking with your healthcare provider.[1]
- In healthy adults, 500 mg of glutathione twice daily for 4 weeks produced no significant change in glutathione status.[2]
- In 54 non-smoking adults, 250 or 1,000 mg a day for 6 months raised glutathione body stores; this trial did not involve losartan.[3]
Do not wait for your next appointment
- Swelling of the face, lips, throat or tongue: get emergency medical help right away and stop taking Cozaar.[1]
- Feeling faint or dizzy: lie down, then call your doctor right away.[1]
- New swelling of the feet, ankles or hands, or weight gain you cannot explain: call your doctor.[1]
- Pregnancy while taking Cozaar: tell your doctor right away.[1]
For the prescriber or pharmacist
- Do I need to space glutathione from losartan at all?
- Which home readings should make me call before my next visit?
- Should my potassium or kidney tests be repeated after I start the supplement?
- Does an IV or injected glutathione product change your advice?
- Is there anything in this product's other ingredients that matters with losartan?
Sources for the facts on this sheet
- Organon LLC, via DailyMed. Cozaar (losartan potassium) tablets, for oral use: prescribing information and patient information. Effective 2026-01-20. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9949448f-c3b9-44ee-94ed-c1aca8c90f39
- Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med 2011. PMID 21875351. https://pubmed.ncbi.nlm.nih.gov/21875351/
- Richie JP Jr, Nichenametla S, Neidig W, et al. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr 2015. PMID 24791752. https://pubmed.ncbi.nlm.nih.gov/24791752/
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.