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Folate sources and MOTS-c product review sheet
List every source of folate you take, why you take it, and the exact MOTS-c product in question. The real problems this can catch, such as doubled-up folate or a medicine that affects folate, have nothing to do with a theoretical MOTS-c interaction.
Every folate source you take
Read the supplement facts panel. Prenatal vitamins, B-complex products and fortified drinks often contain folate too.
| Product | Folate form (folic acid, methylfolate or 5-MTHF, folinic acid) | Amount per serving, as printed | Servings per day | Why you take it |
|---|---|---|---|---|
Your situation
Pregnant, trying, or could become pregnant?
Latest vitamin B12 and folate results, with dates
Medicines that may affect folateask your pharmacist to check your full list
Who recommended your folate, and for what reason
The MOTS-c product in question
Name and salt form exactly as labeled
Seller or pharmacy
Who suggested combining it with a folate product, and why
What the evidence supports
- The US Preventive Services Task Force recommends a daily supplement with 0.4 to 0.8 mg (400 to 800 μg) of folic acid for anyone planning to or who could become pregnant. No MOTS-c finding changes that.[1]
- The only MOTS-c and folic acid test added 100 nM folic acid to cells in a dish; it has never been tested in people.[2]
- FDA's search found no clinical studies giving MOTS-c to people, so no timing gap or preferred folate form has evidence behind it.[3]
- The discovery paper notes that MOTS-c shares several cell effects with the antifolate drug methotrexate. That is a laboratory comparison, not evidence about taking either with folate.[2]
Questions for your pharmacist or clinician
- Is my total folate from all products more than I need, or duplicated?
- Should my B12 be checked before I take larger amounts of folate?
- Does any medicine I take change my folate needs?
- If I am planning pregnancy, is my folic acid plan right, and what is known about MOTS-c in pregnancy?
- Does an MTHFR test result change anything for me, or not?
Sources for the facts on this sheet
- Barry MJ, Nicholson WK, Silverstein M, et al (US Preventive Services Task Force). Folic Acid Supplementation to Prevent Neural Tube Defects: US Preventive Services Task Force Reaffirmation Recommendation Statement. JAMA 2023. PMID 37526713. https://pubmed.ncbi.nlm.nih.gov/37526713/
- Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 2015. PMID 25738459. https://pubmed.ncbi.nlm.nih.gov/25738459/
- U.S. Food and Drug Administration. FDA Briefing Document: MOTS-c-Related Bulk Drug Substances (MOTS-c (free base) and MOTS-c acetate), Pharmacy Compounding Advisory Committee, July 23-24, 2026. Accessed 2026-10-18. https://www.fda.gov/media/193347/download
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.