Back to the article

HealthRX.com · Printable supplement log

Lion's mane on Mounjaro: product, glucose and bruising log

Record the exact lion's mane product, the medicines that change the risk, and two weeks of daily notes on timing, glucose readings, stomach symptoms and bruising. The fact panel separates what was studied in people from laboratory and rat results.

Companion to “Can I Take Lion's Mane with Mounjaro?” · healthrx.com/supplements-mounjaro/with-lions-mane · Facts checked 2026-10-18

The product you take

Brand and product name
Fruiting body, mycelium or bothas worded on the label
Amount per capsule (mg) and capsules per day
Date started
Other supplements taken with it

Medicines that change the picture

Mounjaro dose and injection day
Sulfonylurea or insulin: name and dose
Blood thinner, aspirin or NSAID: name and dose
Known mushroom or mold allergy?

Daily notes for the first two weeks

DateLion's mane: time and amountDays since injectionGlucose reading, if you checkNausea, bloating or fullnessBruising or bleedingNotes

What the cited studies actually measured

  • The human trial: adults aged 50 to 80 with mild cognitive impairment took four 250 mg tablets three times a day for 16 weeks, then were followed for 4 weeks without tablets.[1]
  • Their cognitive scores fell significantly 4 weeks after intake stopped.[1]
  • The platelet effect came from laboratory tests on washed rabbit platelets and on human platelets.[2]
  • The glucose-lowering result came from diabetic rats given 100 or 200 mg/kg of extract for 28 days.[3]
  • Mounjaro's label: combined with a sulfonylurea or insulin, it may raise the risk of low blood sugar, including severe low blood sugar.[4]
  • Mounjaro's Medication Guide asks you to tell your provider about vitamins and herbal supplements.[4]

Get help promptly

  • Low blood sugar signs listed for Mounjaro: dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness or a fast heartbeat.[4]
  • Swelling of your face, lips, tongue or throat, or trouble breathing or swallowing: stop Mounjaro and get medical help right away.[4]

Questions for your prescriber

  1. Does my sulfonylurea or insulin dose need a change if I add lion's mane?
  2. Should the doctor who prescribes my blood thinner or aspirin know about it?
  3. How often should I check my glucose while I try it?
  4. If my nausea or fullness gets worse, which should I pause first?
  5. Is there a reason to avoid it given my allergies?
Sources for the facts on this sheet
  1. Mori K, Inatomi S, Ouchi K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res 2009. PMID 18844328. https://pubmed.ncbi.nlm.nih.gov/18844328/
  2. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine 2010. PMID 20637576. https://pubmed.ncbi.nlm.nih.gov/20637576/
  3. Liang B, Guo Z, Xie F, et al. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med 2013. PMID 24090482. https://pubmed.ncbi.nlm.nih.gov/24090482/
  4. Eli Lilly and Company, via DailyMed. Mounjaro (tirzepatide) injection, for subcutaneous use: prescribing information and Medication Guide. Effective 2026-08-27. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.