HealthRX.com · Printable supplement log
Bedtime glycine and morning NMN or NR: sleep, check-in and lab diary
Record your glycine and NMN or NR doses and times, tick the medicines and conditions this page says to raise with a prescriber, log sleep and stomach effects for the first two weeks, then note a week 3 to 4 check-in and any week 8 labs.
What you take
Glycine product, grams and time before bed
NMN or NR product, mg and time
Other sleep aids or supplements
Prescription medicines
Raise these with your prescriber first (from this page)
- Clozapine or another antipsychotic
- A blood thinner
- Chronic kidney disease
- Blood pressure medicines
- Diabetes medicines, such as metformin or a sulfonylurea
Weeks 1 to 2: nightly log
| Date | Glycine dose and time | Time to fall asleep | Total sleep | Next-day tiredness (0 to 10) | Bloating or loose stools |
|---|---|---|---|---|---|
Weeks 3 to 4 check-in
Energy and focus compared with before
Exercise recovery
Vivid dreams or morning grogginess
Week 8 optional labs
| Test | Date | Result | Notes |
|---|---|---|---|
| Fasting glucose | |||
| HbA1c | |||
| Homocysteine | |||
| AST and ALT |
What the glycine studies used and found
- In a sleep-restriction crossover study analysing seven healthy men, 3 g of glycine 30 minutes before bed lowered rated fatigue compared with placebo on the first day, but not on the third.[1]
- Glycine 60 g a day added to clozapine for 8 weeks produced no significant change in symptoms.[2]
- Creatine synthesis uses about 40% of the labile methyl groups supplied by SAM, but the authors conclude it places no major burden on glycine metabolism in adults, because the body readily makes glycine.[3]
Questions for your clinician
- Is glycine at bedtime suitable with my current medicines?
- Should my homocysteine be checked, given the other supplements I take?
- Does my kidney function change whether glycine suits me?
- If my sleep does not change after two weeks, what should I look at next?
Sources for the facts on this sheet
- Bannai M, Kawai N, Ono K, et al. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol 2012. PMID 22529837. https://pubmed.ncbi.nlm.nih.gov/22529837/
- Evins AE, Fitzgerald SM, Wine L, et al. Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am J Psychiatry 2000. PMID 10784481. https://pubmed.ncbi.nlm.nih.gov/10784481/
- Brosnan JT, da Silva RP, Brosnan ME. The metabolic burden of creatine synthesis. Amino Acids 2011. PMID 21387089. https://pubmed.ncbi.nlm.nih.gov/21387089/
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.