HealthRX.com · Printable medication review sheet
Resveratrol with NMN or NR: prescription, hormone and liver check
Record the trans-resveratrol and NMN or NR doses you take, tick the CYP3A4-processed medicines, hormone treatments and history this page flags, note the liver and kidney results from your next routine blood test, and bring the questions to your prescriber.
What you take
Resveratrol producttrans-resveratrol mg per serving, from the label
Servings a day, and with or without a fatty meal
NMN or NR product and mg a day
Other polyphenol or stilbene blends
Medicines to show the prescriber or pharmacist
- A statin, such as simvastatin or atorvastatin
- A calcium channel blocker, such as amlodipine
- Cyclosporine or another immunosuppressant
- Estradiol, another estrogen, or tamoxifen
- A blood thinner or antiplatelet medicine
- Any other prescription medicine
History to mention
- ER-positive breast cancer, personal or family
- Liver disease or past raised liver enzymes
- Pregnant or breastfeeding
What the human studies measured
- In a study of 42 healthy volunteers, 40 of whom had enzyme tests, resveratrol 1 g a day for 4 weeks raised buspirone exposure, a CYP3A4 measure, by 33%, and also changed CYP2D6, CYP2C9 and CYP1A2 measures. The authors warn this could alter other drugs' effects.[1]
- In that 4-week study, diarrhea was reported by 4 of 42 people (9.5%) and heartburn by 3 (7.1%).[1]
- Of a 25 mg oral dose, at least 70% was absorbed, but only a trace of unchanged resveratrol (under 5 ng/mL) was found in plasma.[2]
Results from your next routine blood test
| Test | Date | Result | Flagged high or low? |
|---|---|---|---|
| Comprehensive metabolic panel | |||
| ALT and AST | |||
| Other |
Report these to your clinician (from this page)
- Diarrhea or nausea lasting more than 48 hours
- Unexplained bruising
- Dark urine, pain under the right ribs, or yellowing skin or eyes
Questions for your prescriber
- Are any of my medicines processed by CYP3A4, and does my resveratrol dose matter for them?
- Should any drug level or lab be checked more often while I take resveratrol?
- Is resveratrol suitable with my hormone therapy or cancer history?
- Is there anything about NMN or NR itself you want me to watch?
Sources for the facts on this sheet
- Chow HH, Garland LL, Hsu CH, et al. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila) 2010. PMID 20716633. https://pubmed.ncbi.nlm.nih.gov/20716633/
- Walle T, Hsieh F, DeLegge MH, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004. PMID 15333514. https://pubmed.ncbi.nlm.nih.gov/15333514/
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.