HealthRX.com · Printable supplement log
Glutathione with Vyvanse: product check and wear-off diary
Check the glutathione product's full ingredient list against the Vyvanse label, then log two weeks of dose times and when the medicine seems to wear off, so any change can be traced to a product rather than guessed at.
The glutathione product
Product name and maker
Routecapsule, liposomal, sublingual, IV or IM
Amount per dose (mg) and doses per day
Other ingredients printed on the label
If injected: clinic name and how often
Ingredient check against the Vyvanse label
- Ascorbic acid or vitamin C listed
- Sodium bicarbonate or another alkalinizing ingredient listed
- Tryptophan or St. John's wort in anything else you take
- Product and dose shown to the prescriber
- Product and dose shown to the pharmacist
Two-week diary
| Date | Vyvanse dose and time | Glutathione dose and time | Other supplements that day | Time the effect seemed to fade | Sleep, appetite or racing heart | Notes |
|---|---|---|---|---|---|---|
From the Vyvanse label and the glutathione trial
- The Vyvanse label says lisdexamfetamine is not metabolized by cytochrome P450 enzymes.[1]
- Dextroamphetamine, the active form, has a half-life of about 10 to 11.3 hours in healthy adults.[1]
- Acidifying agents such as ascorbic acid lower amphetamine blood levels; alkalinizing agents such as sodium bicarbonate raise them.[1]
- Vyvanse is not to be taken during or within 14 days after an MAOI.[1]
- In the 6-month oral glutathione trial, levels returned to baseline after a 1-month washout.[2]
Stop and get help right away
- Possible serotonin syndrome: agitation, flushing, loss of coordination, dizziness, hallucinations, high body temperature or a fast heartbeat. The Medication Guide says to stop Vyvanse and call your provider or go to the emergency room.[1]
- Chest pain, shortness of breath or fainting during treatment: call your healthcare provider or go to the nearest emergency room right away.[1]
For the prescriber
- Could anything in this product change how long Vyvanse lasts for me?
- If the effect seems shorter, should we look at my supplements before changing the dose?
- Do glutathione injections need any extra checks in my case?
- Is it safe with my other medicines, including any antidepressant?
Sources for the facts on this sheet
- Takeda Pharmaceuticals America, via DailyMed. Vyvanse (lisdexamfetamine dimesylate) capsules and chewable tablets, for oral use, CII: prescribing information and Medication Guide. Effective 2026-04-30. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad
- Richie JP Jr, Nichenametla S, Neidig W, et al. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr 2015. PMID 24791752. https://pubmed.ncbi.nlm.nih.gov/24791752/
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.