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Wegovy at 50 to 64: blood pressure and oral-medicine review sheet

A sheet for the visits when your Wegovy dose goes up: home blood pressure and pulse readings, the oral medicines that may need closer checks, and what the label reports about low blood pressure and heart rate, so dose changes to other medicines are decided with numbers in hand.

Companion to “Wegovy Safety in Older Adults (50-64): What the Evidence Shows” · healthrx.com/wegovy/older-adult-safety · Facts checked 2026-10-18

Medicines to bring to the review

Write the dose and the time of day you take each one.

Blood pressure tabletsfor example amlodipine, lisinopril, a beta blocker
Water tablets (diuretics)
Thyroid tablet dose and date of last TSH
Blood thinner and date of last INRwarfarin or another
Oral estrogen, progesterone or other hormone tablets
Diabetes medicinessay if insulin or a sulfonylurea

Home blood pressure and pulse

Seated reading in the morning before tablets; add a standing reading if you feel light-headed.

DateWegovy dose (mg)Blood pressurePulseLight-headed on standing?Notes

What the Wegovy label reports

  • In the heart outcomes trial (mean age 62), systolic pressure at week 104 was 3.8 mmHg lower on Wegovy and 0.5 mmHg lower on placebo.[1]
  • Low blood pressure was reported in 1.3% of Wegovy-treated adults and 0.4% on placebo in the weight-reduction trials.[1]
  • In the weight-reduction trials of the injection, resting heart rate rose by 1 to 4 beats per minute on average compared with placebo.[1]
  • For oral medicines with a narrow therapeutic index or that need monitoring, the label says to consider extra clinical or lab checks.[1]
  • In a drug interaction study with a semaglutide tablet (not the injection), levothyroxine exposure rose 33%.[1]
  • With insulin or a sulfonylurea, the label says to consider lowering that dose when Wegovy is started.[1]

Do not wait for the next visit

  • Any sign of a serious allergic reaction (swelling of the face, lips, tongue or throat, severe rash or itching, a very rapid heartbeat, problems breathing or swallowing, fainting or dizziness): stop Wegovy and get medical help right away.[1]
  • Heart racing or pounding in your chest for several minutes: tell your healthcare provider.[1]
  • Nausea, vomiting or diarrhea that does not go away: tell your healthcare provider right away.[1]

Questions for this review

  1. As my weight falls, which blood pressure tablet would be reduced first, and at what reading?
  2. Which of my tablets need a blood test while my Wegovy dose is going up?
  3. When should my TSH or INR be rechecked?
  4. Would a bone density scan change anything in my plan?
  5. Is 1.7 mg a reasonable place to stay if 2.4 mg is hard to tolerate?

What we agreed

Medicine changes
Blood pressure reading that should prompt a call
Next labs and date
Next review date
Sources for the facts on this sheet
  1. Novo Nordisk, via DailyMed. Wegovy (semaglutide) injection, for subcutaneous use, and Wegovy (semaglutide) tablets, for oral use: prescribing information and Medication Guide. Effective 2026-06-18. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ee06186f-2aa3-4990-a760-757579d8f77b

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.