How to Safely Stop Trazodone: A Step-by-Step Discontinuation Guide
Trazodone withdrawal symptoms (rebound insomnia, anxiety, irritability, nausea and dizziness) begin within 24 to 72 hours and most resolve in 7-14 days.
Trazodone
33 source-based articles maintained by the HealthRX.com Editorial Team.
33articles
6topic areas covered
May 27, 2026latest review
Trazodone library
Showing 33 of 33 clinical reviews.
Is Trazodone a Controlled Substance? Regulatory Status
Trazodone is not a controlled substance; it's a prescription-only SARI approved for depression in the US, EU, Canada, and UK, not for insomnia.
Trazodone After Bariatric Surgery: What Clinicians and Patients Need to Know
A clinical deep-dive into trazodone use after bariatric surgery, covering pharmacokinetic changes, dose adjustments, drug interactions, and evidence on sleep and depression in post-bariatric patients.
Trazodone and Cognitive Function: What the Evidence Actually Shows
A clinician-level review of how trazodone affects memory, attention, processing speed, and next-day cognition, covering pharmacology, trial data, and practical prescribing guidance.
Trazodone Appetite & Cravings Changes: What the Evidence Actually Shows
A clinician-level review of how trazodone affects appetite, food cravings, and body weight, covering receptor pharmacology, clinical trial data, and practical management strategies.
Trazodone Before Surgery: Confirm the Plan Instead of Counting Hold Days
There is no universal seven-day trazodone hold before surgery. Confirm your individualized medication, fasting, and restart plan with your care team.
Trazodone Bone Health and Density Impact
A clinical review of trazodone's effects on bone mineral density, fracture risk, and fall risk, covering mechanisms, trial data, and prescribing guidance for patients on long-term trazodone therapy.
Trazodone Cancer Risk Signal Review: What the Evidence Actually Shows
A clinician-level review of the trazodone cancer risk signal, covering pharmacoepidemiologic data, proposed mechanisms, regulatory status, and practical prescribing guidance for depression and off-label insomnia.
Trazodone Cost vs. Alternatives: A Class-by-Class Pricing and Efficacy Comparison
Compare trazodone's cost against SSRIs, Z-drugs, orexin antagonists, and low-dose doxepin for depression and insomnia. Includes per-pill pricing, trial data, and clinical trade-offs.
Trazodone Dosing for Older Adults (50 to 64): What Clinicians and Patients Should Know
Evidence-based guide to trazodone dosing in adults aged 50 to 64, covering starting doses, titration, off-label insomnia use, drug interactions, and age-specific safety considerations.
Trazodone Dosing in Renal Impairment: Evidence-Based Adjustments for Kidney Disease
Trazodone is not nephrotoxic, but its active metabolite mCPP builds up in kidney disease. Start at 25 mg nightly if eGFR is under 30 and titrate slowly.
Trazodone Drug-Drug Interactions: A Complete Clinical Profile
Evidence-based guide to trazodone drug-drug interactions, covering CYP3A4 inhibitors, serotonin syndrome risk, QT prolongation, and CNS depressant combinations with FDA and PubMed citations.
Trazodone Food & Supplement Interactions: What to Eat, Avoid, and Watch
A guide to trazodone interactions with food, alcohol, herbs, and supplements. Includes mechanisms, timing strategies, and PubMed-cited evidence.
Trazodone Geriatric (65+) Dosing: Safe Starting Doses, Titration, and Monitoring
Evidence-based guide to trazodone dosing in adults 65 and older, covering starting doses for insomnia and depression, titration schedules, fall risk, drug interactions, and deprescribing strategies.
Trazodone Geriatric (65+) Monitoring: Lab Tests, Fall Risk, and Safety Checks
Evidence-based monitoring guide for trazodone in adults 65 and older, covering baseline labs, orthostatic blood pressure, fall risk assessment, QTc screening, renal dosing, and deprescribing protocols.
Trazodone Hair and Skin Changes: What Patients and Clinicians Need to Know
A guide to trazodone's documented effects on hair and skin, including alopecia reports, dermatologic reactions, and how to manage them in practice.
Trazodone Liver Function Impact: What the Evidence Actually Shows
Is trazodone bad for your liver? Serious liver injury is rare, under 1 case per 100,000 patient-years; mild enzyme rises usually reverse after stopping.
Trazodone Manufacturing, Supply & Shortage History
A clinical review of trazodone's manufacturing base, FDA shortage events, supply chain vulnerabilities, and what prescribers should know about generic availability in 2024-2025.
Trazodone Missed-Dose Protocol: What to Do and Why It Matters
A guide to trazodone missed-dose management, mechanism of action, pharmacokinetics, and evidence-based prescribing for depression and off-label insomnia.
Trazodone Off-Label Uses and Their Evidence Levels
Trazodone is approved only for depression, but 80% of scripts are off-label. See evidence grades for insomnia, agitation, PTSD nightmares, anxiety, and pain.
Trazodone Patent History and Generic Timeline: What Clinicians and Patients Should Know
A detailed look at trazodone's patent history, generic availability, current formulations, and what the future holds for this widely prescribed antidepressant and sleep aid.
Trazodone Pharmacokinetics (ADME): How the Drug Is Absorbed, Distributed, Metabolized, and Excreted
A physician-level review of trazodone pharmacokinetics covering absorption, distribution, metabolism by CYP3A4, active metabolite mCPP, and renal excretion, with cited primary sources.
Trazodone Pregnancy Category C: What It Means
Trazodone is FDA Category C. No clear malformation signal in studies, but watch for neonatal adaptation syndrome near delivery. Breastfeeding transfer is under 3%.
Trazodone Rebound Effects When Stopping: What Patients and Clinicians Need to Know
A clinician-level review of trazodone rebound and withdrawal effects when stopping, covering insomnia rebound, discontinuation timelines, tapering approaches, and the evidence behind off-label sleep use.
Trazodone Safety in Older Adults (50 to 64): Risks, Dosing, and What Your Doctor Should Monitor
Evidence-based safety guide for trazodone use in adults aged 50 to 64, covering cardiac risks, orthostatic hypotension, drug interactions, and dosing adjustments.
Trazodone Safety in Older Adults (65+): Risks, Dosing, and Monitoring
Evidence-based guide to trazodone safety in geriatric patients aged 65 and older, covering fall risk, orthostatic hypotension, drug interactions, dosing adjustments, and deprescribing strategies.
Trazodone Safety in Young Adults (18-29): What the Evidence Says
A clinical review of trazodone safety for young adults aged 18 to 29, covering the FDA black box warning, dosing, side effects, sexual health, and monitoring protocols.
Trazodone Schedule for Adults 30-49: Depression and Sleep
Trazodone dosing for ages 30-49: 150-400 mg/day divided for depression, 25-100 mg at bedtime for insomnia. Includes titration steps and max dose limits.
Trazodone Seasonal Use Considerations: A Clinical Guide
How seasonal factors, including winter light deprivation, summer heat, and circadian disruption, affect trazodone dosing, tolerability, and safety across the year. MD/PharmD-level guidance with primary-literature citations.
Trazodone Sleep Architecture Impact: What the Evidence Actually Shows
A clinical deep-dive into how trazodone alters sleep stages, slow-wave sleep, REM suppression, and spindle activity, with primary-literature citations for physicians, pharmacists, and informed patients.
Trazodone Storage: Match the Container, Date and Exposure
Record trazodone’s exact package, printed dates and storage exposure so a pharmacist or manufacturer can assess the product and replacement needs.
Trazodone Switching Protocols: How to Switch From or To Trazodone Safely
A clinician-level guide to switching trazodone to or from other antidepressants, sleep agents, and related drugs. Covers mechanism, cross-tapering schedules, washout periods, and serotonin syndrome risk with specific doses and trial data.
Trazodone Travel and Timezone-Shift Protocols: A Clinical Guide
How to time trazodone doses during transmeridian travel, manage jet lag, and adjust schedules across time zones. MD/PharmD-level protocols with primary-literature citations.